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February 1, 2005The Journal of ImmunologyOpen Access

Defective Proximal TCR Signaling Inhibits CD8+ Tumor-Infiltrating Lymphocyte Lytic Function

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Authors

MKMythili Koneru490 BioTech (United States)DSDavid SchaerBayer (United States)NMNgozi MonuCornell University

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Cite This Study

Koneru et al. (2005) studied this question.

synapsesocial.com/papers/6a11175d233310799074e5achttps://doi.org/10.4049/jimmunol.174.4.1830
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function1998 · 2,014 citations
  2. 2CD8+ Tumor-Infiltrating T Cells Are Deficient in Perforin-Mediated Cytolytic Activity Due to Defective Microtubule-Organizing Center Mobilization and Lytic Granule Exocytosis2001 · 161 citations
  3. 3T Cell Receptor Signaling Precedes Immunological Synapse Formation2002 · 692 citations
  4. 4Developmental Regulation of Lck Targeting to the CD8 Coreceptor Controls Signaling in Naive and Memory T Cells1999 · 155 citations