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May 23, 2026Current Computer - Aided Drug Design

Integrating Network Pharmacology and Molecular Docking to Decipherthe Anti-fibrotic Role of Fuzheng Xiezhuo Decoction via NLRP3/TNF-α/IL-6 Pathway in Renal Fibrosis

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Authors

ZTZhiying TengZZZeyu ZhangZWZ Wang

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Overview

Randomized trial studies Fuzheng Xiezhuo Decoction's effect on renal fibrosis, indicating new therapeutic targets.

Key Points

  • The study aims to investigate the anti-fibrotic effects of Fuzheng Xiezhuo Decoction on renal fibrosis via specific molecular pathways.
  • Utilized network pharmacology and molecular docking to identify active components and mechanisms of FZXZD.
  • Verified effects using an adenine-induced renal fibrosis rat model.
  • Conducted histopathological examinations and Western blot analyses to assess fibrotic and inflammatory markers.
  • FZXZD improved renal function in adenine-induced nephropathy rats, showing a significant reduction in renal tissue damage.
  • Down-regulated fibrosis mediators (TGF-β, Smad2/3) and inflammatory cytokines (NLRP3, TNF-α, IL-6) were observed after treatment.
  • Histological analysis confirmed the effectiveness of FZXZD in alleviating renal fibrosis progression.

Cite This Study

Teng et al. (2026) studied this question.

synapsesocial.com/papers/6a1144f948a409a3a49defe8https://doi.org/10.2174/0115734099393969260403205303
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