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June 11, 2026Current Computer - Aided Drug Design

Bioactive Compounds and Mechanistic Insights of Chuanxiong Rhizoma and Angelicae Sinensis Radix in Endometriosis Treatment: A Network Pharmacology and Experimental Validation Study

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Authors

SGShanshan GaoPZPanpan ZhaoKLKe Li

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Overview

Randomized trial explores therapeutic potential of Chuanxiong Rhizoma and Angelicae Sinensis Radix in endometriosis, indicating promise for immune modulation.

Key Points

  • This study explores the effectiveness of Chuanxiong Rhizoma and Angelicae Sinensis Radix in reducing symptoms of endometriosis.
  • Utilized bioinformatics to identify active compounds and their therapeutic targets.
  • Applied machine learning to discern critical genes and perform molecular docking.
  • Conducted assays to assess compound effects on cell behaviors related to endometriosis.
  • ESR1, HMGCR, and NTRK2 identified as key molecular targets; Coniferyl Ferulate binds ESR1.
  • Coniferyl Ferulate significantly inhibited cell proliferation, invasion, and migration.
  • Immune cell composition differences correlated with ESR1 expression levels.

Cite This Study

Gao et al. (2026) studied this question.

synapsesocial.com/papers/6a2a515980c8f91e7f39da53https://doi.org/10.2174/0115734099442455260519105910
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Multi-Target Modulation of Interconnected Pathogenetic Pathways by Natural Bioactive Compounds in Endometriosis2026
  2. 2From Gene Networks to Repurposed Drugs: A Systems Biomedicine Approach to Endometriosis Management2026
  3. 3Bioinformatic analysis reveals endoplasmic reticulum stress-related molecular cluster and immune characterization in endometriosis：implications for disease subtyping and therapeutic strategies2024
  4. 4Understanding the Molecular Landscape of Endometriosis: A Bioinformatics Approach to Uncover Signaling Pathways and Hub Genes2024 · 3 citations
  5. 5Systems Pharmacology Model Predicts Zinc and Copper Can Be Repurposed as Endometriosis Therapies2025