Key result
Active pediatric chronic rheumatic heart disease is linked to elevated TNF-α, CRP, PCT and lower IL-10.
Why the study?
Chronic rheumatic heart disease is an important acquired cardiovascular disease in children and adolescents, characterized by progressive valvular damage, myocardial inflammation, and chronic cardiac insufficiency.
Do serum levels of IL-10, TNF-α, CRP, and PCT have diagnostic and prognostic significance in children with active chronic rheumatic heart disease?
Observational
Do serum levels of IL-10, TNF-α, CRP, and PCT have diagnostic and prognostic significance in children with active chronic rheumatic heart disease?
Elevated TNF-α, CRP, and PCT with reduced IL-10 are associated with active inflammatory stages of chronic rheumatic heart disease in children and may serve as diagnostic and prognostic biomarkers.
Answers are grounded in this paper and cite their sources.
May support biomarker monitoring in active pediatric chronic RHD; hypothesis-generating and requires prospective validation.
Chronic rheumatic heart disease (CRHD) remains one of the most important acquired cardiovascular diseases in children and adolescents. The disease develops due to autoimmune inflammatory reactions after group A beta-hemolytic streptococcal infection and is characterized by progressive valvular damage, myocardial inflammation, and chronic cardiac insufficiency. The present study investigated serum levels of interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-α), C-reactive protein (CRP), and procalcitonin (PCT) in children with CRHD. Elevated TNF-α, CRP, and PCT together with reduced IL-10 were observed during active inflammatory stages. These biomarkers demonstrated high diagnostic and prognostic significance.
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Khurshid Jumaniyozovich Bobojonov (2026) conducted an observational in Chronic rheumatic heart disease. Immuno-biochemical markers (IL-10, TNF-α, CRP, PCT) was evaluated on Diagnostic and prognostic significance of serum biomarkers. Serum levels of TNF-α, CRP, and PCT were elevated, while IL-10 was reduced, during active inflammatory stages of chronic rheumatic heart disease in children.
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