Why the study?
RHD remains a major cause of preventable morbidity in low- and middle-income countries, and clarity was needed on the systemic immune signatures associated with valvular pathology.
Systemic immune profiling in acute rheumatic fever and rheumatic heart disease reveals specific T cell and pro-inflammatory cytokine signatures that mirror local valve inflammation and may serve as prognostic markers.
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These signatures may flag ARF progression risk and RHD fibrotic targets; extends tissue data but leaves open prospective biomarker validation.
Neves et al. (2025) studied this question.
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