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May 23, 2026Abstract and Applied AnalysisOpen Access

Optimal Control and Global Sensitivity Analysis of a Multiroute Zika Transmission Model With Wolbachia

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Authors

ASAbdoulaye SowCDCherif DialloHCHocine Cherifi

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Overview

Randomized trial examines Zika transmission control in populations, suggesting effective multitarget strategies.

Key Points

  • This work aims to develop an integrated model for Zika transmission and evaluate control strategies involving Wolbachia and sexual prevention.
  • Developed an SICR–SI mathematical model for Zika transmission including human and mosquito populations.
  • Calibrated model parameters using epidemiological data from seven Pacific island archipelagos.
  • Applied optimal control theory and global sensitivity analysis (Sobol indices) to determine intervention strategies.
  • Wolbachia significantly reduces vector transmission, but Zika persists due to sexual transmission.
  • Combining Wolbachia with sexual prevention leads to a greater reduction in incidence than using each strategy alone.
  • Sensitivity analysis reveals mosquito-related parameters and Wolbachia coverage greatly influence epidemic outcomes.

Cite This Study

Sow et al. (2026) studied this question.

synapsesocial.com/papers/6a1145b048a409a3a49df6aahttps://doi.org/10.1155/aaa/1574642
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