Why the study?
The impact of time in target range of systolic blood pressure on cardiovascular disease and all-cause mortality had not yet been elucidated in young and middle-aged adults with hypertension.
Does a higher time in target range of systolic blood pressure reduce new-onset cardiovascular disease and all-cause mortality in young and middle-aged adults with hypertension?
Population
21,855 participants under 60 with hypertension in the Kailuan study
Comparison
Groups across increasing time in target range of systolic blood pressure (120 to 140 mm Hg)
Design
Longitudinal cohort analysis
Follow-up
Through December 2022
Key result
Higher systolic blood pressure time in target range (120-140 mm Hg) was associated with up to a 31% decreased risk for new-onset CVD and a 34% decreased risk for all-cause mortality.
Authors
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Supports SBP-TTR monitoring in young hypertensives; leaves open whether targeting it improves outcomes in trials.
Cohort (n=21,855)
Does a higher time in target range of systolic blood pressure reduce new-onset cardiovascular disease and all-cause mortality in young and middle-aged adults with hypertension?
Effect estimate: Risk reduction 31% (CVD) and 34% (mortality) in highest SBP-TTR group
In young and middle-aged adults with hypertension, maintaining systolic blood pressure within the target range of 120-140 mmHg for a greater proportion of time is associated with progressively lower risks of new-onset cardiovascular disease and all-cause mortality.
Luo et al. (2026) conducted a cohort in Hypertension (n=21,855). Time in target range of systolic blood pressure (SBP-TTR) vs. Lower SBP-TTR groups was evaluated on New-onset CVD and all-cause mortality (Risk reduction 31% (CVD) and 34% (mortality) in highest SBP-TTR group). Higher systolic blood pressure time in target range (120-140 mm Hg) was associated with up to a 31% decreased risk for new-onset CVD and a 34% decreased risk for all-cause mortality.