Review synthesizes mechanisms of curcumin in osteomyelitis, indicating its potential as an adjunct therapy.
Key Points
This review explores the pharmacological properties of curcumin in treating osteomyelitis, focusing on its molecular mechanisms and delivery strategies.
Synthesized evidence from preclinical models regarding curcumin's role in osteomyelitis treatment.
Explored the effects of curcumin on biofilm reduction, inflammatory pathways, and osteogenic potential.
Discussed delivery strategies such as nanocarriers and surface coatings for improving curcumin's efficacy.
Curcumin enhances bacterial clearance and improves osteoblast function in preclinical models.
Combination of curcumin with standard antibiotics decreases biofilm burden in device-related infection models.
Standardized formulations and controlled trials are necessary for clinical translation of curcumin.