Key result
Rare benign perinephric myxoid pseudotumors mimic malignant lesions in end-stage kidney disease.
Why the study?
Perinephric myxoid pseudotumor of fat is a very rare benign perirenal mass that can mimic malignant lesions such as liposarcoma on imaging in patients with advanced kidney disease.
PMPF is a rare, benign perirenal mass in kidney transplant recipients with allograft loss that mimics malignancy on imaging and requires careful histologic differentiation.
Awareness may avert misdiagnosis of incidental perirenal masses in re-transplant candidates; leaves open questions on prevalence and management.
Perinephric myxoid pseudotumor of fat (PMPF) is a very rare, benign perirenal mass that has been described in patients with advanced and inflammatory kidney disease. On imaging, PMPF can mimic benign and malignant lesions ranging from simple cysts to poorly differentiated malignant liposarcoma. Histologically, it consists of adipose cells, myxoid stroma, spindle cells and inflammatory cells, mainly lymphocytes. Herein, we report on our center's experience with PMPF in kidney transplant recipients with allograft loss presenting for re-transplant evaluation and provide a review of the existing literature. PMPF often presents as an incidental radiologic finding in end-stage kidney disease patients undergoing evaluation for re-transplantation. It may represent a localized reaction to renal parenchymal inflammation often caused by recurrent rejection, or chronic immunologic intolerance of previous allografts. PMPF is benign but should be differentiated from malignant entities such as well-differentiated liposarcoma.
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Sridhara et al. (2026) conducted a review in Perinephric myxoid pseudotumor of fat. Perinephric myxoid pseudotumor of fat is a rare, benign perirenal mass often found incidentally in end-stage kidney disease patients undergoing re-transplant evaluation, mimicking malignant lesions.
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