Key result
Higher TyG index and ePWV linked to ~39% greater risk of hypertension onset.
Why the study?
The study aimed to assess the association of the triglyceride-glucose index and estimated pulse wave velocity with the risk of hypertension in a population from Northwest China.
Are higher TyG index and ePWV associated with an increased risk of incident hypertension?
Cohort (n=1,189)
Are higher TyG index and ePWV associated with an increased risk of incident hypertension?
Both TyG index and ePWV are significant independent predictors of incident hypertension, suggesting their potential value in early risk assessment.
Answers are grounded in this paper and cite their sources.
TyG index may flag higher hypertension risk; leaves open causal validation and clinical utility in trials.
This study aimed to assess the association of the triglyceride-glucose (TyG) index and estimated pulse wave velocity (ePWV) with the risk of hypertension in a population from Northwest China, using data from a prospective cohort of 1189 participants in Ningxia. The TyG index and ePWV were calculated, and Cox proportional hazards regression models were used to assess their association with hypertension incidence. Additionally, restricted cubic spline analysis was employed to explore nonlinear relationships between the TyG index, ePWV, and hypertension. Over follow-up, blood pressure levels were higher than at baseline. The risk of hypertension onset progressively increased with rising TyG index and ePWV (TyG: HR = 1.459, 95% CI 1.250-1.702; ePWV: HR = 1.277, 95% CI 1.191-1.369). After adjusting for confounding factors, the associations remained significant (TyG: HR = 1.392, 95% CI 1.165-1.662; ePWV: HR = 1.453, 95% CI 1.253-1.685). Furthermore, the TyG index showed a linear association with hypertension, whereas ePWV exhibited a nonlinear relationship, highlighting their potential value in early risk assessment in this high-risk population.
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Wang et al. (2026) conducted a cohort in hypertension (n=1,189). Triglyceride-glucose (TyG) index and estimated pulse wave velocity (ePWV) was evaluated on hypertension incidence (HR 1.392, 95% CI 1.165-1.662). Higher TyG index and ePWV were significantly associated with an increased risk of hypertension onset (adjusted HR 1.392, 95% CI 1.165-1.662 for TyG; adjusted HR 1.453, 95% CI 1.253-1.685 for ePWV).
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