Key result
Vital exhaustion in healthy men was associated with significantly elevated levels of PAI-1 activity (median 13.0 U/ml vs. 6.0 U/ml; p=0.023) compared to non-exhausted controls.
Why the study?
Is vital exhaustion associated with impaired fibrinolytic capacity and increased coagulation factors in otherwise healthy men?
Case-Control (n=30)
Is vital exhaustion associated with impaired fibrinolytic capacity and increased coagulation factors in otherwise healthy men?
Absolute Event Rate: 13% vs 6%
p-value: p=0.023
Vital exhaustion is associated with reduced fibrinolytic capacity (elevated PAI-1 activity), suggesting a potential mechanism for its role as a risk factor for myocardial infarction.
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Supports impaired fibrinolysis as a correlate of vital exhaustion; hypothesis-generating for MI risk mediation and needs prospective confirmation.
Kop et al. (1998) conducted a case-control in Vital exhaustion (n=30). Vital exhaustion vs. Not-exhausted controls was evaluated on PAI-1 activity (p=0.023). Vital exhaustion in healthy men was associated with significantly elevated levels of PAI-1 activity (median 13.0 U/ml vs. 6.0 U/ml; p=0.023) compared to non-exhausted controls.
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