Key result
High-throughput RT-PCR profiling of 71 ionic channel genes successfully classified distinct regional expression patterns in the sinoatrial node, atrioventricular node, atria, and ventricles of mice.
This study provides the first genome-scale regional ionic channel expression profile in the mouse heart, identifying specific molecular determinants of pacemaker activity.
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No immediate clinical impact; leaves open translation of mouse ionic channel profiles to human arrhythmias.
Marionneau et al. (2004) studied this question. High-throughput RT-PCR profiling of 71 ionic channel genes successfully classified distinct regional expression patterns in the sinoatrial node, atrioventricular node, atria, and ventricles of mice.
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