Key result
Living >300 km from cardiac centers is linked to ~43% higher infant mortality in moderate CHD.
Why the study?
Socioeconomic status affects outcomes in severe congenital heart disease, but the impact of socioeconomic status and remoteness of residence on congenital heart disease outcomes in Canada needed examination.
Do socioeconomic status and remoteness of residence impact in-hospital mortality in infants with congenital heart disease requiring intervention?
Cohort (n=7,711)
Yes
Do socioeconomic status and remoteness of residence impact in-hospital mortality in infants with congenital heart disease requiring intervention?
Effect estimate: aOR 1.43 (95% CI 1.11-1.84)
In a universal healthcare system, greater remoteness of residence and lower socioeconomic status are associated with higher in-hospital mortality in infants with moderate, but not severe, congenital heart disease.
Remoteness and low SES were associated with higher mortality in moderate CHD; hypothesis-generating for targeted access interventions before practice change.
Background Socioeconomic status (SES) impacts clinical outcomes associated with severe congenital heart disease (sCHD). We examined the impact of SES and remoteness of residence (RoR) on congenital heart disease (CHD) outcomes in Canada, a jurisdiction with universal health insurance. Methods and Results All infants born in Canada (excluding Quebec) from 2008 to 2018 and hospitalized with CHD requiring intervention in the first year were identified. Neighborhood level SES income quintiles were calculated, and RoR was categorized as residing <100 km, 100 to 299 km, or >300 km from the closest of 7 cardiac surgical programs. In‐hospital mortality at <1 year was the primary outcome, adjusted for preterm birth, low birth weight, and extracardiac pathology. Among 7711 infants, 4485 (58 . 2%) had moderate CHD (mCHD) and 3226 (41.8%) had sCHD. Overall mortality rate was 10.5%, with higher rates in sCHD than mCHD (13.3% versus 8.5%, respectively). More CHD infants were in the lowest compared with the highest SES category (27.1% versus 15.0%, respectively). The distribution of CHD across RoR categories was 52.3%, 21.3%, and 26.4% for <100 km, 100 to 299 km, and >300 km, respectively. Although SES and RoR had no impact on sCHD mortality, infants with mCHD living >300 km had a higher risk of mortality relative to those living <100 km (adjusted odds ratio [aOR], 1.43 [95% CI, 1.11–1.84]). Infants with mCHD within the lowest SES quintile and living farthest away had the highest risk for mortality (aOR, 1.74 [95% CI, 1.08–2.81]). Conclusions In Canada, neither RoR nor SES had an impact on outcomes of infants with sCHD. Greater RoR, however, may contribute to higher risk of mortality among infants with mCHD.
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Olugbuyi et al. (2022) conducted a cohort in Congenital heart disease (n=7,711). Remoteness of residence and socioeconomic status vs. Living <100 km and highest socioeconomic status was evaluated on In-hospital mortality at <1 year (aOR 1.43, 95% CI 1.11-1.84). Living >300 km from a cardiac center increased mortality risk for infants with moderate congenital heart disease compared to living <100 km (aOR 1.43; 95% CI 1.11-1.84), but did not impact severe CHD.
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