Key result
Prenatal diagnosis of transposition of the great arteries reduced preoperative mortality (0% vs 6%, P<0.05) and postoperative mortality (0% vs 8.5%, P<0.01) compared to postnatal diagnosis.
Why the study?
Does prenatal diagnosis reduce preoperative and postoperative mortality and morbidity in neonates with Transposition of the Great Arteries compared to postnatal diagnosis?
Population
318 neonates with Transposition of the Great Arteries (TGA) over a 10-year period
Comparison
Prenatal diagnosis of TGA vs Postnatal diagnosis of TGA
Design
Cohort
Follow-up
Hospital stay
Authors
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Supports expanded prenatal TGA screening; hypothesis-generating and requires prospective confirmation before changing practice.
Cohort (n=318)
Does prenatal diagnosis reduce preoperative and postoperative mortality and morbidity in neonates with Transposition of the Great Arteries compared to postnatal diagnosis?
Absolute Event Rate: 0% vs 6%
p-value: p=<0.05
Prenatal diagnosis of transposition of the great arteries significantly reduces preoperative and postoperative mortality and improves clinical condition at admission compared to postnatal diagnosis.
Bonnet et al. (1999) conducted a cohort in Transposition of the great arteries (n=318). Prenatal diagnosis vs. Postnatal diagnosis was evaluated on Preoperative mortality (p=<0.05). Prenatal diagnosis of transposition of the great arteries reduced preoperative mortality (0% vs 6%, P<0.05) and postoperative mortality (0% vs 8.5%, P<0.01) compared to postnatal diagnosis.
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