High Levels of Lp(a) With a Small Apo(a) Isoform Are Associated With Coronary Artery Disease in African American and White Men
Key result
Elevated Lp(a) levels (≥30 mg/dL) with small apo(a) isoforms (<22 kringle 4 repeats) independently predicted the risk for CAD in African American and white men (P<0.01), but not in women.
Why the study?
Does the combination of elevated Lp(a) levels and small apo(a) isoform size predict the presence of CAD in African American and white men and women?
Population
576 white and African American men and women
Comparison
Elevated Lp levels with small apo isoforms vs Lower Lp(a) levels or large apo(a) isoforms
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Does not yet support isoform-adjusted Lp(a) testing for CAD risk; hypothesis-generating for sex-specific thresholds in men.
Study Design
Type
Observational (n=576)
Structured PICO
Does the combination of elevated Lp(a) levels and small apo(a) isoform size predict the presence of CAD in African American and white men and women?
P
Population
576 white and African American men and women
I
Intervention
Elevated Lp(a) levels (≥30 mg/dL) with small apo(a) isoforms (<22 kringle 4 repeats)
C
Comparator
Lower Lp(a) levels or large apo(a) isoforms
O
Outcome
Presence of coronary artery disease (CAD) defined as ≥50% stenosissurrogate
Main Result
p-value: p=<0.01
Elevated Lp(a) levels combined with small apo(a) isoform size independently predict CAD risk in both African American and white men, explaining the previously observed racial disparities when using Lp(a) levels alone.
Cite This Study
Paultre et al. (2000) conducted an observational in Coronary artery disease (n=576). Elevated Lp(a) levels (≥30 mg/dL) with small apo(a) isoforms (<22 kringle 4 repeats) vs. Absence of elevated Lp(a) or small apo(a) isoforms was evaluated on Presence of CAD (≥50% stenosis) (p=<0.01). Elevated Lp(a) levels (≥30 mg/dL) with small apo(a) isoforms (<22 kringle 4 repeats) independently predicted the risk for CAD in African American and white men (P<0.01), but not in women.