Key result
Normothermic cardiopulmonary bypass did not compromise the efficacy of cold myocardial protection compared to hypothermia, with no differences in peak and cumulative serum troponin release.
Why the study?
Does normothermic cardiopulmonary bypass increase myocardial injury compared to hypothermic bypass in patients undergoing coronary artery bypass surgery with cold cardioplegia?
Population
66 patients with stable angina pectoris undergoing coronary artery bypass surgery
Comparison
Normothermic or moderate hypothermic… vs Hypothermic cardiopulmonary bypass, with cold…
Design
RCT, prospectively randomized into three groups
Follow-up
up to 5 days
Authors
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Normothermic CPB maintains cold cardioplegia efficacy in CABG; confirms safety and supports flexible temperature strategies in future trials.
RCT (n=66)
1:1:1
Does normothermic cardiopulmonary bypass increase myocardial injury compared to hypothermic bypass in patients undergoing coronary artery bypass surgery with cold cardioplegia?
Normothermic cardiopulmonary bypass does not compromise the efficacy of cold myocardial protection compared to hypothermic bypass in low-risk patients undergoing CABG.
Birdi et al. (1999) conducted an RCT in Stable angina pectoris undergoing coronary artery bypass surgery (n=66). Normothermic systemic perfusion (37°C) vs. Hypothermia (28°C) and moderate hypothermia (32°C) was evaluated on Peak and cumulative serum troponin release. Normothermic cardiopulmonary bypass did not compromise the efficacy of cold myocardial protection compared to hypothermia, with no differences in peak and cumulative serum troponin release.
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