Key result
Patients with major depression and thoracic aortic atherosclerosis exhibited increased platelet stimulation compared to normal subjects, suggesting heightened platelet reactivity.
Why the study?
Do patients with major depression, dialysis-dependence, or thoracic aortic atherosclerosis exhibit increased markers of platelet activation and secretion compared to normal subjects?
Population
49 subjects comprising normal comparison subjects, patients with DSM-IV major depression, dialysis-dependent…
Comparison
Diagnosis of DSM-IV major depression… vs Normal comparison subjects
Design
Cross-sectional
Authors
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May link depression to excess CV risk via platelet reactivity; hypothesis-generating, needing prospective confirmation.
Observational (n=49)
Do patients with major depression, dialysis-dependence, or thoracic aortic atherosclerosis exhibit increased markers of platelet activation and secretion compared to normal subjects?
Patients with major depression exhibit increased platelet activation comparable to patients with severe thoracic aortic atherosclerosis, providing a potential biological mechanism for their increased cardiovascular risk.
Musselman et al. (2002) conducted an observational in Major depression, thoracic aortic atherosclerosis, renal dialysis (n=49). Major depression, thoracic aortic atherosclerosis, or renal dialysis vs. Normal comparison subjects was evaluated on Markers of in vivo platelet stimulation and secretion (anti-LIBS platelet binding, beta-thromboglobulin). Patients with major depression and thoracic aortic atherosclerosis exhibited increased platelet stimulation compared to normal subjects, suggesting heightened platelet reactivity.
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