Key result
A review of abdominal aortic aneurysm pathophysiology highlights that while the disease is more common in men, women face a greater risk of rupture and worse prognosis.
This review highlights sex differences in abdominal aortic aneurysm pathophysiology, noting that while men have higher incidence, women face greater rupture risk and worse prognosis.
May warrant sex-specific AAA surveillance thresholds; leaves open validation in prospective cohorts.
Abdominal aortic aneurysm (AAA) is a vascular disorder with a high case fatality rate in the instance of rupture. AAA is a multifactorial disease, and the etiology is still not fully understood. AAA is more likely to occur in men, but women have a greater risk of rupture and worse prognosis. Women are reportedly protected against AAA possibly by premenopausal levels of estrogen and are, on average, diagnosed at older ages than men. Here, we review the present body of research on AAA pathophysiology in humans, animal models, and cultured cells, with an emphasis on sex differences and sex steroid hormone signaling.
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Boese et al. (2018) conducted a review in Abdominal aortic aneurysm. A review of abdominal aortic aneurysm pathophysiology highlights that while the disease is more common in men, women face a greater risk of rupture and worse prognosis.
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