Key result
A single walk at moderate intensity reduced systolic blood pressure for 5 hours post-exercise (p-interaction<0.04), specifically in ACE I allele carriers but not in DD individuals.
Why the study?
Does a single walking session reduce acute blood pressure in medicated hypertensive patients, and is this response modified by ACE gene polymorphisms?
RCT (n=34)
cross-over
Does a single walking session reduce acute blood pressure in medicated hypertensive patients, and is this response modified by ACE gene polymorphisms?
p-value: p=0.06
Postexercise hypotension following a moderate-intensity walk in medicated hypertensive patients appears to be dependent on ACE gene polymorphisms, occurring in carriers of the I allele but not in DD individuals.
ACE genotype may guide acute BP responses to walking in hypertensives; extends evidence on I/D polymorphism as a modifier of postexercise hypotension.
HYPOTHESIS/INTRODUCTION: Polymorphisms of the angiotensin converting enzyme (ACE) gene can interfere with exercise-induced acute blood pressure (BP) reduction. This cross-over study investigated the acute effect of a single walk on BP and tested whether polymorphisms of the ACE gene might explain the variation in BP responses. MATERIALS AND METHODS: Thirty-four healthy medicated individuals were randomized to one control and one walking session at 60-75% of heart rate reserve. Subjects left the laboratory wearing an ambulatory BP monitor until waking the next morning. RESULTS: Overall, systolic BP was somewhat lower following the walking session (p=.06), which could be attributed to a consistently lower systolic BP for 5 h after exercise (p-interaction<.04) compared with control rest. Similarly, II/ID individuals had a lower systolic BP (p-interaction=.02) and diastolic BP (p-interaction<.01) for 5 h after walking compared with control rest. Among DD individuals, a single walk did not induce a reduction in BP (p-interaction>.05). CONCLUSIONS: Our results showed that postexercise hypotension can occur after a walk at moderate intensity in carriers of the I allele; we were not able to demonstrate this in DD individuals. Our results suggest that genetic variation in the ACE gene might affect the BP response to exercise, although more research is needed to confirm these findings.
No takes yet. Share an insight, caveat, or question.
Goessler et al. (2015) conducted an RCT in medicated hypertensive patients (n=34). walking session vs. control rest was evaluated on acute blood pressure reduction (p=0.06). A single walk at moderate intensity reduced systolic blood pressure for 5 hours post-exercise (p-interaction<0.04), specifically in ACE I allele carriers but not in DD individuals.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: