Key result
Ischemic heart disease in women is characterized by less coronary atherosclerosis than in men, with coronary endothelial dysfunction and microvascular disease acting as important mechanisms.
Why the study?
Cardiovascular disease is a leading cause of morbidity and death among women, with increasing recognition of sex differences in the prevalence, presentation, and pathophysiology of ischemic heart disease.
This review highlights sex-specific differences in ischemic heart disease, emphasizing the role of coronary endothelial dysfunction and microvascular disease in women.
May inform sex-specific IHD assessment in women; hypothesis-generating for targeted microvascular trials.
Cardiovascular disease is a leading cause of morbidity and death among women. Our knowledge of ischemic heart disease has grown tremendously over the past few decades as sex differences in prevalence, presentation, and pathophysiology are increasingly being recognized. Women with ischemic heart disease have less coronary atherosclerosis than men. Coronary endothelial dysfunction and microvascular disease have been proposed as important mechanisms that contribute to the cause and prognosis of ischemic heart disease in women. This review outlines sex-specific issues in ischemic heart disease, including prevalence, prognosis, pathophysiology, traditional and nontraditional risk factors, screening, and diagnostic testing, as well as management strategies.
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Waheed et al. (2019) conducted a review in Ischemic heart disease. Ischemic heart disease in women is characterized by less coronary atherosclerosis than in men, with coronary endothelial dysfunction and microvascular disease acting as important mechanisms.
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