Key result
Target trial emulation frameworks improve the credibility of observational research in critical care by reducing biases such as immortal time bias and aligning eligibility and follow-up.
Discusses the use of target trial emulation designs to improve the credibility of causal inference from observational research in critical care.
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Decker et al. (2025) conducted an editorial in Critical care. Target trial emulation vs. Traditional observational designs was evaluated. Target trial emulation frameworks improve the credibility of observational research in critical care by reducing biases such as immortal time bias and aligning eligibility and follow-up.
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