A Common Inhibitory Receptor for Major Histocompatibility Complex Class I Molecules on Human Lymphoid and Myelomonocytic Cells
Authors
Discussion
Loading...
Member takes
Implication
Laboratory study reveals widespread inhibitory receptor ILT2 expression on human leukocytes, indicating self-MHC class I recognition universally restrains immune activation.
Key Points
- To characterize the expression pattern and inhibitory functional properties of the novel immunoglobulin-superfamily receptor ILT2 across human lymphoid and myelomonocytic cell lineages.
- Analyzed the cellular distribution of the Ig-like transcript (ILT)2 receptor across human natural killer cells, T cells, B cells, monocytes, macrophages, and dendritic cells.
- Evaluated the functional effects of ILT2-MHC class I interactions on NK and T cell cytotoxicity, as well as on calcium mobilization triggered via B cell antigen receptors and HLA-DR.
- ILT2 is expressed across multiple leukocyte lineages, including subsets of NK and T cells, as well as B cells, monocytes, macrophages, and dendritic cells.
- Ligation of ILT2 to MHC class I molecules inhibited target cell killing by NK and T cells and suppressed intracellular calcium mobilization in B cells and myelomonocytic cells.
- Myelomonocytic cells expressed homologous, highly polymorphic ILT2-related receptors that potentially recognize distinct HLA class I molecules.
Cite This Study
Colonna et al. (1997) studied this question.