Key result
The reported nonlinear dose-response curve associating one cigarette per day with half the cardiovascular risk of 20 cigarettes per day is likely attributable to methodological oversights.
Why the study?
To critique and re-evaluate the nonlinear dose-response curve plotted by Hackshaw and colleagues associating one cigarette per day with half the cardiovascular disease risk of 20 cigarettes per day.
Does low cigarette consumption significantly reduce the risk of coronary heart disease and stroke compared to higher consumption?
Does low cigarette consumption significantly reduce the risk of coronary heart disease and stroke compared to higher consumption?
The apparent disproportionately high cardiovascular risk of light smoking compared to heavy smoking reported in previous meta-analyses may be a statistical and behavioral artifact rather than a true biological effect.
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Zvi Herzig (2021) conducted a review in Coronary heart disease and stroke. Low cigarette consumption vs. 20 cigarettes per day was evaluated on Cardiovascular disease risk. The reported nonlinear dose-response curve associating one cigarette per day with half the cardiovascular risk of 20 cigarettes per day is likely attributable to methodological oversights.
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