January 14, 1986Biochemistry
Resolution of highly purified toxic-shock syndrome toxin 1 into two distinct proteins by isoelectric focusing
Population
Highly purified toxic-shock syndrome toxin 1 (TSST-1) from Staphylococcus aureus strains
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
Distinguishes TSST-1 isoforms in animal models; leaves open whether variants alter human pathogenesis or targeted interventions.
Structured PICO
P
Population
Highly purified toxic-shock syndrome toxin 1 (TSST-1) from Staphylococcus aureus strains
I
Intervention
Isoelectric focusing and biochemical characterization
O
Outcome
Resolution into distinct proteins and characterization of their properties (isoelectric points, molecular weights, amino acid compositions, immunological reactivity, biological activities)surrogate
TSST-1 consists of two distinct proteins with different isoelectric points but identical biological and immunological properties, likely due to a cofactor or alternative conformations.
Cite This Study
Blomster-Hautamaa et al. (1986) studied this question.