Why the study?
Is clinical worsening in relapsing-remitting multiple sclerosis associated with increased frequency and area of gadolinium-enhancing MRI lesions?
Population
9 patients with mild relapsing-remitting multiple sclerosis (Expanded Disability Status Scale [EDSS] <3.5)
Design
Cohort
Follow-up
24 to 37 months
Authors
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May support Gd-MRI monitoring in RRMS; leaves open whether lesions independently predict worsening.
Is clinical worsening in relapsing-remitting multiple sclerosis associated with increased frequency and area of gadolinium-enhancing MRI lesions?
Smith et al. (1993) studied this question.
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