Consider an unbiased follow-up study designed to investigate the causal effect of a dichotomous exposure on a dichotomous disease outcome. Under a deterministic outcome model, a standard '95 per cent binomial confidence interval' may fail to cover the causal parameter of interest at the nominal rate when we take the causal parameter to be a parameter associated with the observed study population (regardless of whether the observed study population was sampled from a larger superpopulation). I propose new interval estimators that, in this setting, improve upon the performance of the standard 'binomial confidence interval.'
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James M. Robins (1988) studied this question.
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