Key result
Elevated uric acid is linked to higher cardiac death risk in conservatively treated HOCM.
Why the study?
The role of uric acid in the survival of patients with hypertrophic obstructive cardiomyopathy had not been fully evaluated.
Is uric acid concentration associated with cardiac death in patients with hypertrophic obstructive cardiomyopathy?
Cohort (n=317)
No
Is uric acid concentration associated with cardiac death in patients with hypertrophic obstructive cardiomyopathy?
Elevated uric acid concentration may serve as an independent risk factor for cardiac death in patients with hypertrophic obstructive cardiomyopathy.
Answers are grounded in this paper and cite their sources.
May support uric acid monitoring in hypertrophic obstructive cardiomyopathy; leaves open whether lowering it improves outcomes.
BACKGROUND: The role of uric acid (UA) in survival of patients with hypertrophic obstructive cardiomyopathy (HOCM) has not been fully evaluated. This study aimed to determine whether UA could be an independent risk factor of cardiac death in patients with HOCM. METHODS: = 106). CONCLUSIONS: UA concentration was found to be independently associated with cardiac death in HOCM patients receiving conservative treatment. Randomized trials of UA-lowering agents for HOCM patients are warranted.
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Gao et al. (2021) conducted a cohort in Hypertrophic obstructive cardiomyopathy (HOCM) (n=317). Uric acid was evaluated on Cardiac death (HR 1.005, 95% CI 1.001-1.009, p=0.009). Elevated uric acid concentration was independently associated with an increased risk of cardiac death (HR 1.005) in patients with hypertrophic obstructive cardiomyopathy receiving conservative treatment.
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