Key result
Aspirin therapy in patients with atrial fibrillation reduced the relative risk of ischemic stroke by 21% compared with placebo (95% CI 0%-38%; P=.05).
Why the study?
Does aspirin reduce ischemic stroke in patients with atrial fibrillation?
Population
Patients with atrial fibrillation from 3 randomized trials, mean age 70 years, 62% male.
Comparison
Aspirin 75 mg, 300 mg, or 325 mg daily vs Placebo
Design
Meta-analysis, Randomized, Double-blind
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Aspirin may warrant consideration for stroke prevention in atrial fibrillation when anticoagulation is unsuitable; confirms modest benefit versus placebo in pooled data.
Meta-Analysis
Double-blind
Yes
Does aspirin reduce ischemic stroke in patients with atrial fibrillation?
Effect estimate: RRR 21% (95% CI 0%-38%)
p-value: p=.05
Aspirin provides a small reduction in the relative risk of ischemic stroke (21%) in patients with atrial fibrillation compared to placebo.
A 1997 study conducted a meta-analysis in Atrial fibrillation. Aspirin vs. Placebo was evaluated on ischemic stroke (RRR 21%, 95% CI 0%-38%, p=.05). Aspirin therapy in patients with atrial fibrillation reduced the relative risk of ischemic stroke by 21% compared with placebo (95% CI 0%-38%; P=.05).
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