Key result
Stage II PVD patients had a worse apolipoprotein profile than controls (p<0.01), and those with an ankle/arm pressure index <0.6 had higher triglycerides and VLDL-C (p<0.05).
Why the study?
Are apolipoproteic profiles altered in patients with stage II peripheral vascular disease compared to normal controls, and do they correlate with disease severity as measured by ankle/arm pressure index?
Case-Control (n=127)
Are apolipoproteic profiles altered in patients with stage II peripheral vascular disease compared to normal controls, and do they correlate with disease severity as measured by ankle/arm pressure index?
p-value: p=<0.01
Stage II peripheral vascular disease is associated with an atherogenic apolipoprotein profile, and greater disease severity correlates with hypertriglyceridemia and higher VLDL-C.
Stage II PVD associated with atherogenic apolipoprotein profile; hypothesis-generating for severity correlation, needs prospective validation.
The aim of the study was to provide a detailed apolipoproteic profile in stage II peripheral vascular disease (PVD) patients and to ascertain whether lower ankle/ arm pressure index (API) values were associated with a worse profile. Apolipoproteins of 83 stage II PVD patients (average age 64.7 ± 9.3 years) were selected and compared with those of a group of 44 normal control subjects, similar in terms of age, sex, and smoking and eating habits. Neither PVD patients nor controls had ever received lipid-lowering agents or defined dietary treatment. A diagnosis of PVD was confirmed by an API of <0.85. Arteriopathic patients were also split into two groups, depending on their API values, similar in terms of age, sex and smoking habits: API values of one group (n = 38) were ≥0.6, those of the other group (n = 45) were <0.6. The following biohumoral parameters were considered: fasting glycemia, total cholesterol, triglycerides (TGs); high-density lipoprotein cholesterol (HDL-C); low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C), total cholesterol (TC)/HDL-C (TC/ HDL-C), Apoproteins (Apos) AI, AII, B, CII, CIII, and E; and lipoprotein a [Lp(a)]. HDL-C and Apo AI were lower ( p < 0.01), while TC/ HDL-C ratios, Apo B, and Apo CII were higher ( p < 0.01) in PVD patients compared with controls. The comparison between the two PVD groups with different API values showed higher blood TG and VLDL-C values for the patients with lower API values (p < 0.05), indicating a relationship between hypertriglyceridemia and greater arterial damage.
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Catalano et al. (1997) conducted a case-control in Stage II peripheral vascular disease (PVD) (n=127). Stage II PVD and lower API (<0.6) vs. Normal controls and higher API (≥0.6) was evaluated on Apolipoproteic profile and biohumoral parameters (p=<0.01). Stage II PVD patients had a worse apolipoprotein profile than controls (p<0.01), and those with an ankle/arm pressure index <0.6 had higher triglycerides and VLDL-C (p<0.05).
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