Key result
Endothelial cells actively transport lipids and rely on fatty acid metabolism for angiogenesis.
Why the study?
Compared to glucose, how endothelial cells transport lipids and the role of lipids in normal endothelial function have garnered less attention.
This review highlights the emerging understanding of lipid uptake, transport, and utilization in endothelial cells, which is crucial for normal endothelial function and angiogenesis.
Endothelial lipid pathways merit mechanistic study in vascular disease; leaves open clinical translation pending targeted trials.
Endothelial cells (ECs) line all vessels of all vertebrates and are fundamental to organismal metabolism. ECs rely on their metabolism both to transport nutrients in and out of underlying parenchyma, and to support their own cellular activities, including angiogenesis. ECs primarily consume glucose, and much is known of how ECs transport and consume glucose and other carbohydrates. In contrast, how lipids are transported, and the role of lipids in normal EC function, has garnered less attention. We review here recent developments on the role of lipids in endothelial metabolism, with a focus on lipid uptake and transport in quiescent endothelium, and the use of lipid pathways during angiogenesis.
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Kim et al. (2022) conducted a review in Endothelial Lipid Metabolism. Endothelial cells actively take up and transport lipids to underlying parenchyma and rely on both fatty acid synthesis and oxidation for angiogenesis, highlighting the central role of lipid biology in endothelial metabolism.
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