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February 1, 1994CirculationOpen Access

Therapeutic effect of anti-tumor necrosis factor-alpha antibody on the murine model of viral myocarditis induced by encephalomyocarditis virus.

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Why the study?

Does anti-TNF-alpha monoclonal antibody improve survival and reduce myocardial lesions in a murine model of viral myocarditis?

Population

Four-week-old DBA/2 mice inoculated intraperitoneally with encephalomyocarditis virus to induce viral…

Comparison

Recombinant human TNF-alpha or anti-murine… vs Control group

Design

Preclinical

Follow-up

14 days

Authors

TYToshiyuki YamadaMitsubishi Motors (Japan)AMAkira MatsumoriKanazawa UniversitySSS SasayamaDoshisha University

Discussion

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Implication

Pre-treatment anti-TNF-alpha may attenuate early murine viral myocarditis; hypothesis-generating and should not yet change practice.

Structured PICO

Does anti-TNF-alpha monoclonal antibody improve survival and reduce myocardial lesions in a murine model of viral myocarditis?

P
Population
Four-week-old DBA/2 mice inoculated intraperitoneally with encephalomyocarditis virus (EMCV) to induce viral myocarditis
I
Intervention
Recombinant human TNF-alpha (1 microgram daily) or anti-murine TNF-alpha monoclonal antibody (2 x 10^3 units daily) injected intravenously starting on day -1, day 0, or day 1
C
Comparator
Control group (infected mice not receiving the active intervention)
O
Outcome
Myocardial virus content on day 5, histopathological severity of myocardial lesions, and survival rates on day 14surrogate

Anti-TNF-alpha monoclonal antibody may prevent the early pathway of acute viral myocarditis when administered prior to infection in a murine model.

Cite This Study

Yamada et al. (1994) studied this question.

synapsesocial.com/papers/6a11d8f68095bbd48eb4cf44https://doi.org/10.1161/01.cir.89.2.846

Topics

Myocarditis
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