Key result
DOAC transition and appropriate dosing linked to reduced ischemic stroke risk in East Asian AF patients.
Why the study?
East Asian populations have a high burden of AF and AF-related ischemic strokes, with regional diversity in patient characteristics and varying adherence to the ABC pathway.
Answers are grounded in this paper and cite their sources.
The transition to appropriate DOAC dosing and adherence to the ABC pathway are crucial for reducing the high burden of AF-related ischemic stroke in East Asian populations.
East Asian populations exhibit a high burden of atrial fibrillation (AF) and AF-related ischemic strokes. The countries/regions in East Asia have diversities regarding patient characteristics and varying patient care represented by different adherence rates to the ABC (Atrial Fibrillation Better Care) pathway. Two changes, "from non-anticoagulation to direct oral anticoagulants (DOACs)" and "from lower dosing to appropriate dosing DOACs", have been identified in East Asia and have been temporally linked to improved clinical outcomes in AF patients. Additional efforts are necessary to further reduce the stroke risk among AF patients, including increased communication with other specialists/societies, the initiation of prospective studies or clinical trials in Asia, and the implementation of evidence-based holistic or integrated care management based on the ABC pathway.
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Chao et al. (2025) conducted a review in Atrial fibrillation. Direct oral anticoagulants (DOACs) vs. Non-anticoagulation or Warfarin was evaluated. The transition to direct oral anticoagulants and appropriate dosing has been temporally linked to a reduced risk of ischemic stroke among atrial fibrillation patients in East Asia.
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