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November 1, 1996Circulation Research

Mechanical Strain Increases Smooth Muscle and Decreases Nonmuscle Myosin Expression in Rat Vascular Smooth Muscle Cells

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Population

Neonatal rat vascular smooth muscle cells cultured on silicone elastomer plates

Comparison

Cyclic (1-Hz) mechanical strain for 3 to 72 hours vs Unstrained control cells

Design

Preclinical

Follow-up

up to 72 hours

Authors

PRPeter ReuschRuhr University BochumHWHisham M. WagdyMayo ClinicRRRegina ReuschUniversity of Miami

Discussion

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Implication

Preclinical strain effects on VSMC differentiation warrant no clinical change; leaves open ECM-dependent mechanisms in human vascular disease.

Structured PICO

P
Population
Neonatal rat vascular smooth muscle cells cultured on silicone elastomer plates
I
Intervention
Cyclic (1-Hz) mechanical strain for 3 to 72 hours
C
Comparator
Unstrained control cells
O
Outcome
Expression of myosin heavy chain isoforms (SM-1, SM-2, nonmuscle myosin A and B) and their mRNA levelssurrogate

Mechanical strain promotes a more differentiated state in vascular smooth muscle cells by increasing smooth muscle myosin and decreasing nonmuscle myosin expression, an effect dependent on the extracellular matrix.

Cite This Study

Reusch et al. (1996) studied this question.

synapsesocial.com/papers/6a11dba83f4fe1a84cb4d015https://doi.org/10.1161/01.res.79.5.1046
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mechanical strain and collagen potentiate mitogenic activity of angiotensin II in rat vascular smooth muscle cells.1993 · 101 citations
  2. 2Platelet-derived growth factor-BB-induced suppression of smooth muscle cell differentiation.1992 · 184 citations
  3. 3Myosin heavy chain isoform distribution in normal and hypertrophied rat aortic smooth muscle1991 · 11 citations
  4. 4Cleavage of a smooth muscle myosin heavy chain near its C terminus by alpha-chymotrypsin. Effect on the properties of myosin.1991 · 32 citations
  5. 5Regulation of differentiation of vascular smooth muscle cells1995 · 1,733 citations