Key result
Controlling for recalibration response shift revealed a significant improvement in physical functioning scores over 1 year (p < 0.01) among hypertensive patients with coronary artery disease.
Why the study?
Does controlling for response shift and measurement bias alter the perceived change in health-related quality of life over 1 year in hypertensive patients with coronary artery disease?
RCT (n=788)
randomized
Does controlling for response shift and measurement bias alter the perceived change in health-related quality of life over 1 year in hypertensive patients with coronary artery disease?
p-value: p=< 0.01
Accounting for response shift and measurement bias is crucial in longitudinal studies, as it can reveal significant improvements in patient-reported health-related quality of life that would otherwise be masked.
May unmask masked HRQoL gains in hypertensive CAD; leaves open routine correction pending prospective validation.
The purpose of this study was to examine the influence of explanatory and confounding variables on health-related quality of life after accounting for response shift, measurement bias and response shift in measurement using structural equation modeling. Hypertensive patients with coronary artery disease randomized to anti-hypertensive treatment, completed the ShortForm-36 questionnaire at both baseline and 1 year (n = 788). Three measurement biases were found and all three were considered as response shift in measurement. Older patients reported worse scores for both physical functioning (PF) and role-physical at baseline and 1 year later compared to younger patients; and males reported better PF than females after conditioning on the latent trait of general physical health. Before controlling for response shift, patients' PF scores were not statistically different over time; however, PF scores significantly improved (p < 0.01) after controlling for recalibration response shift. Assessment of how patients perceive their change in health-related quality of life over time is warranted.
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Gandhi et al. (2013) conducted an RCT in Hypertensive patients with coronary artery disease (n=788). anti-hypertensive treatment was evaluated on physical functioning (PF) scores (p=< 0.01). Controlling for recalibration response shift revealed a significant improvement in physical functioning scores over 1 year (p < 0.01) among hypertensive patients with coronary artery disease.
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