Expression of transfected human interferon-gamma DNA: evidence for cell-specific regulation.
Population
Mouse T lymphoblast cell line and NIH 3T3 fibroblasts transfected with genomic human IFN-gamma 8.6 Kb BamH…
Comparison
Stimulation with Interleukin 2 and phorbol ester vs Comparison between cell types and unstimulated…
Design
Preclinical
Authors
Discussion
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Implication
Suggests lymphoid-intrinsic IFN-gamma control; leaves open relevance to human T-cell responses in cardiovascular inflammation.
Structured PICO
P
Population
Mouse T lymphoblast cell line and NIH 3T3 fibroblasts transfected with genomic human IFN-gamma 8.6 Kb BamH DNA fragment
I
Intervention
Stimulation with Interleukin 2 (IL 2) and phorbol ester
C
Comparator
Comparison between cell types (T lymphoblast vs fibroblasts) and unstimulated cells
O
Outcome
mRNA expression and synthesis of human IFN-gammasurrogate
Extracellular regulation of IFN-gamma expression appears to be controlled by developmental mechanisms intrinsic to lymphoid lineage cells.
Cite This Study
Young et al. (1986) studied this question.