Key result
Detaching the sinus node in adult rat hearts unmasked ectopic pacemaking in the atrioventricular ring, which exhibited sinus node-like pacemaker mechanisms and was potentiated by isoproterenol.
Why the study?
Atrioventricular rings are a source of ectopic activity in focal atrial tachycardia, but experimental data offering mechanistic insights into the initiation and maintenance of ectopic foci are lacking.
Ectopic pacemaker activity in the atrioventricular rings of adult rat hearts is driven by sinus node-like mechanisms, which can be unmasked when the sinus node is compromised.
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Highlights potential AV ring backup pacemakers in rat sinus node dysfunction; leaves open human translation.
Logantha et al. (2019) studied Ectopic pacemaker activity. Sinus node detachment and pharmacological modulation vs. Intact sinus node or baseline conditions was evaluated on Spontaneous cycle length and pacemaker action potentials. Detaching the sinus node in adult rat hearts unmasked ectopic pacemaking in the atrioventricular ring, which exhibited sinus node-like pacemaker mechanisms and was potentiated by isoproterenol.
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