Regional differences in rabbit atrial repolarization: importance of transient outward current

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Population

Rabbit atrial tissue (left and right atrial roof areas)

Comparison

4-Aminopyridine and pacing at various cycle… vs Right atrial roof area vs left atrial roof area…

Design

Preclinical

Authors

Discussion

I(to) kinetics may drive regional atrial repolarization differences in rabbits; leaves open translation to human AF mechanisms.

Population

Rabbit atrial tissue (left and right atrial roof areas)

Intervention

4-Aminopyridine (4-AP; 1 mM) and pacing at various cycle lengths (2,000, 1,500, 1,000, 800, and 500 ms)

Comparator

Right atrial roof area vs left atrial roof area; baseline vs 4-AP

Outcome

Action potential parameters including phase 1 amplitude, APD40, and phase 3 repolarization ratesurrogate

Different kinetics of the transient outward current (I(to)) play an important role in regional differences of atrial repolarization in rabbits.

Qi et al. (1994) studied this question.

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