Key result
The transient outward current, Ito, was identified as the major factor contributing to action potential differences between left and right rabbit atrial cells.
Population
Rabbit atrial cells (left and right atria) - computational models
Design
Preclinical
Authors
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Ito heterogeneity may guide targeted antiarrhythmic development; leaves open translation to human AF vulnerability.
Computational modeling identifies the transient outward current (Ito) as the primary driver of action potential heterogeneity between left and right rabbit atria, highlighting it as a potential antiarrhythmic target.
Aslanidi et al. (2008) studied Atrial arrhythmias. Action potential models for left and right rabbit atrial cells was evaluated on Regional differences in electrical action potential properties. The transient outward current, Ito, was identified as the major factor contributing to action potential differences between left and right rabbit atrial cells.
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