Key result
Transthyretin amyloid cardiomyopathy was associated with left atrial dilatation and thrombotic event risk over 5 years compared to nonamyloid left ventricular hypertrophy.
Why the study?
Thrombotic event risk is high in ATTR-CM, prompting exploration of left atrial remodeling and its association with thrombotic event risk compared to other LVH phenotypes.
Does ATTR-CM increase the risk of thrombotic events compared to nonamyloid LVH?
Cohort (n=405)
Does ATTR-CM increase the risk of thrombotic events compared to nonamyloid LVH?
ATTR-CM is associated with left atrial cardiopathy and thrombotic events compared to other LVH phenotypes.
BACKGROUND: Thrombotic event (TE) risk is high in transthyretin amyloid cardiomyopathy (ATTR-CM). OBJECTIVES: The authors sought to explore left atrial (LA) remodeling in ATTR-CM and its association with TE risk in comparison to other phenotypes of left ventricular hypertrophy (LVH). METHODS: Subjects who underwent speckle tracking echocardiography, Tc-99m pyrophosphate scintigraphy, serum and urine immune electrophoresis, per registry protocol, were retrospectively identified (n = 405). Cardiac magnetic resonance and endomyocardial biopsy were used per clinical indication. Subjects with cardiac amyloidosis other than ATTR-CM were excluded, those with nonamyloid LVH served as controls. Propensity score matching was performed for age, sex, coronary artery disease, and diabetes. Longitudinal follow-up was performed over 5 years for TEs. CONCLUSIONS: -VASc, and LA dilatation, unlike other LVH phenotypes.
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Özbay et al. (2025) conducted a cohort in Transthyretin amyloid cardiomyopathy (ATTR-CM) (n=405). Transthyretin amyloid cardiomyopathy (ATTR-CM) vs. Nonamyloid left ventricular hypertrophy (LVH) was evaluated on Thrombotic events (TEs). Transthyretin amyloid cardiomyopathy was associated with left atrial dilatation and thrombotic event risk over 5 years compared to nonamyloid left ventricular hypertrophy.
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