Key result
The rate of change of albuminuria over 1 year (log10) independently predicted all-cause mortality (HR 1.76; 95% CI 1.39-3.11) and cardiovascular mortality (HR 1.57; 95% CI 1.13-5.22).
Why the study?
Does the rate of change of albuminuria over 1 year predict mortality and cardiovascular events in patients with diabetic nephropathy?
Population
427 patients with diabetic nephropathy defined as urinary albumin excretion >= 30 mg/24 h at baseline, mean…
Design
Cohort
Follow-up
average of 5 years
Authors
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May refine mortality risk stratification in diabetic nephropathy; leaves open whether targeting albuminuria change improves outcomes.
Cohort (n=427)
Does the rate of change of albuminuria over 1 year predict mortality and cardiovascular events in patients with diabetic nephropathy?
Effect estimate: HR 1.76 (95% CI 1.39-3.11)
The rate of change of albuminuria over 1 year is an independent predictor of mortality and cardiovascular events in patients with diabetic nephropathy, highlighting its utility as a clinical risk marker.
Yuyun et al. (2003) conducted a cohort in diabetic nephropathy (n=427). Rate of change of albuminuria was evaluated on all-cause mortality (HR 1.76, 95% CI 1.39-3.11). The rate of change of albuminuria over 1 year (log10) independently predicted all-cause mortality (HR 1.76; 95% CI 1.39-3.11) and cardiovascular mortality (HR 1.57; 95% CI 1.13-5.22).
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