Why the study?
Invasive coronary functional tests can identify angina mechanisms in patients with ANOCA, but whether non-invasive tests can also reliably assess these mechanisms was unknown.
Do non-invasive coronary functional tests using transthoracic Doppler echocardiography correlate with invasive coronary functional tests in identifying the mechanisms of angina in patients with ANOCA?
Population
18 patients with ANOCA who underwent I-CFTs and 13 healthy controls
Comparison
NI-CFTs vs I-CFTs and healthy controls
Design
Observational comparative study
Key result
Non-invasive hyperventilation testing strongly correlated (Φ coefficient 0.71) with invasive acetylcholine testing for detecting coronary vasospasm in patients with non-obstructed coronary arteries.
Authors
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Non-invasive coronary functional testing using transthoracic Doppler echocardiography shows high diagnostic agreement with invasive testing in patients with ANOCA, offering a potential non-invasive alternative for assessing angina mechanisms.
Observational (n=31)
Single-blind
No
Do non-invasive coronary functional tests using transthoracic Doppler echocardiography correlate with invasive coronary functional tests in identifying the mechanisms of angina in patients with ANOCA?
Effect estimate: Φ coefficient 0.71
p-value: p=0.002
Non-invasive coronary functional testing using transthoracic Doppler echocardiography shows high diagnostic agreement with invasive testing in patients with ANOCA, offering a potential non-invasive alternative for assessing angina mechanisms.
Cambise et al. (2026) conducted an observational in Angina and non-obstructed coronary arteries (ANOCA) (n=31). Non-invasive coronary functional tests (NI-CFTs) vs. Invasive coronary functional tests (I-CFTs) was evaluated on Correlation between coronary vasoconstriction during hyperventilation test and vasospastic response during invasive acetylcholine test (Φ coefficient 0.71, p=0.002). Non-invasive hyperventilation testing strongly correlated (Φ coefficient 0.71) with invasive acetylcholine testing for detecting coronary vasospasm in patients with non-obstructed coronary arteries.