Key result
Higher CAC scores are linked to increased white matter hyperintensity risk in asymptomatic individuals.
Why the study?
Calcification plays a major role in atherosclerosis, but the correlation between coronary artery calcium score, cerebral large artery atherosclerosis, and cerebral small vessel disease required analysis.
Does elevated coronary artery calcium score correlate with cerebral large artery atherosclerosis and small vessel disease in patients undergoing medical checkups?
Cross-Sectional (n=521)
No
Does elevated coronary artery calcium score correlate with cerebral large artery atherosclerosis and small vessel disease in patients undergoing medical checkups?
Effect estimate: OR 1.009 (95% CI 1.004-1.014)
p-value: p=0.001
Elevated coronary artery calcium score strongly correlates with both cerebral large artery disease and small vessel disease, suggesting its utility in detecting early or subclinical cerebral artery disease.
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Supports CACS-cerebral small vessel link on imaging; leaves open screening utility and requires prospective validation.
Noh et al. (2025) conducted a cross-sectional in Asymptomatic individuals undergoing health screening (n=521). Coronary artery calcium score (CACS) was evaluated on White matter hyperintensity (WMH) (OR 1.009, 95% CI 1.004-1.014, p=0.001). Higher coronary artery calcium scores were significantly associated with increased odds of white matter hyperintensity (OR 1.009) and other cerebral artery diseases in asymptomatic individuals.
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