Key result
Preoperative antibiotics are linked to a ~5-day longer postoperative hospital stay vs no antibiotics.
Why the study?
Surgical site infections are associated with longer postoperative hospital stays, prompting an exploration of factors associated with prolonged stays in a primary rural Ethiopian hospital lacking microbiological confirmation facilities.
Does preoperative antibiotic use affect postoperative length of hospital stay in surgical patients?
Observational (n=75)
No
Does preoperative antibiotic use affect postoperative length of hospital stay in surgical patients?
Effect estimate: +5.3 days (95% CI 1.67-8.87)
p-value: p=0.005
Improper use of preoperative antibiotics and older age are associated with significantly longer postoperative hospital stays in rural Ethiopian surgical patients.
Should not yet change preoperative antibiotic protocols; leaves open whether the association reflects confounding in this observational cohort.
Introduction: surgical site infection is associated with longer postoperative hospital stays. We explored factors associated with longer postoperative hospital stays among patients in the surgical ward of a primary rural hospital in Ethiopia, where laboratory facilities for microbiological confirmation of surgical site infections were not available. Methods: July 2018. Data were taken from paper-based medical records and patient interviews. The primary outcome was postoperative length of hospital stay. Data were analyzed by multivariable linear regression using Stata software, version 13. Results: seventy-five patients were enrolled, sociodemographic data was obtained from 14 of these patients by interview, and 44 patients had complete outcome and covariate data and were included in regression analysis. Median length of preoperative hospital stay was 3.0 (interquartile range 2.0) days. Postoperative length of hospital stay was longer by 3.8 days (95% confidence interval (CI) 1.05-6.55; p=0.008), 4.7 days (95% CI 1.64-7.66; p=0.004), and 5.9 days (95% CI 2.70-9.02; p=0.001), for patients 35-54 years, 55-64 years and the 65+ years respectively, compared to patients who were 18-34 years of age. Patients who received preoperative antibiotics stayed 5.3 days longer (95% CI 1.67-8.87; p=0.005) compared to those who were not given preoperative antibiotics. Conclusion: age and improper use of preoperative antibiotics compound the risk for postoperative length of stay. Infection prevention protocols, including staff training, and surveillance for surgical site infections are critical for improving hospital outcomes.
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Kebede et al. (2024) conducted an observational in Surgical patients (n=75). Preoperative antibiotics vs. No preoperative antibiotics was evaluated on Postoperative length of hospital stay (+5.3 days, 95% CI 1.67-8.87, p=0.005). Preoperative antibiotics were associated with a 5.3-day longer postoperative hospital stay (95% CI 1.67-8.87; p=0.005) compared to no preoperative antibiotics among surgical patients.
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