Why the study?
Are there gender- and age-related differences in the treatment and control of cardiovascular risk factors among dyslipidemic, hypertensive patients with and without angina?
Are there gender- and age-related differences in the treatment and control of cardiovascular risk factors among dyslipidemic, hypertensive patients with and without angina?
Significant gender disparities exist in the management of cardiovascular risk factors, with high-risk women being less likely to receive statins or achieve LDL-C control compared to men.
Potential undertreatment of women with angina warrants clinician awareness; leaves open causal mechanisms and targeted interventions.
Dyslipidemic, hypertensive patients (N = 48,863) were stratified by gender, age, and angina (n = 2502) vs. nonangina (n = 46,358) status. Comparing 95% confidence intervals yielded significant differences in treatment and cardiovascular risk factor control between subgroups. More men than women had low-density lipoprotein cholesterol (LDL-C) <100 mg/dL (angina, 43.94-43.96 vs. 34.42-34.50; nonangina, 32.43-32.43 vs. 17.25-17.25) and 100-129 mg/dL (angina, 32.12-32.14 vs. 35.10-35.18; nonangina, 53.86-53.86 vs. 32.44-32.44). More women than men had LDL-C > or = 130 mg/dL (angina, 27.68-27.72 vs. 23.91-23.93; nonangina, 38.70-38.70 vs. 35.38-35.39). Women were less likely than men to receive statins (angina, 69.95-69.99 vs. 82.11-82.13; nonangina, 59.80-59.80 vs. 63.72-63.72), any antilipidemic medication at all (angina, 25.93-25.97 vs. 13.48-13.48; nonangina, 36.73-36.73 vs. 30.73-30.73), or to have current cholesterol measurements (angina, 56.82-56.88 vs. 34.54-34.56; nonangina, 45.77-45.77 vs. 39.75-39.75). Primary care providers treat high-risk patients relatively aggressively; however, opportunities to forestall cardiovascular disease may be missed in hypertensive, dyslipidemic women whose LDL-C is often not measured and controlled.
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Hendrix et al. (2005) studied this question.
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