Thyroid transcription factor-1 (TTF-1) is a tissue specific transcription factor expressed in epithelial cells of the thyroid and lung, as well as in certain areas of the brain. Recent investigations have shown that TTF-1 is also commonly present in a wide variety of thyroid and lung tumors. Because of its restrictive expression, TTF-1 is a useful immunohistochemical marker in the diagnosis of tumors of thyroid or lung origin.
No takes yet. Share an insight, caveat, or question.
Nelson G. Ordóñez (2000) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: