What question did this study set out to answer?

To assess the efficacy, onset of action, and safety profile of pregabalin compared with lorazepam and placebo in patients with generalized anxiety disorder.

February 28, 2003American Journal of Psychiatry

Pregabalin in Generalized Anxiety Disorder: A Placebo-Controlled Trial

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To assess the efficacy, onset of action, and safety profile of pregabalin compared with lorazepam and placebo in patients with generalized anxiety disorder.
In a double-blind trial, 276 patients with DSM-IV generalized anxiety disorder were randomly assigned to pregabalin (150 mg/day or 600 mg/day), lorazepam (6 mg/day), or placebo.
The regimen consisted of a 1-week placebo lead-in, 4 weeks of active treatment, and a 1-week taper, evaluating the Hamilton Anxiety Rating Scale total score as the primary endpoint.
Mean baseline-to-endpoint reductions in Hamilton Anxiety Rating Scale scores were significantly greater with pregabalin 150 mg/day (-9.2), pregabalin 600 mg/day (-10.3), and lorazepam (-12.0) than with placebo (-6.8), with pregabalin showing significant improvement by week 1.
Trial completion rates were 90% (62 of 69) for pregabalin 150 mg/day, 71% (50 of 70) for pregabalin 600 mg/day, 73% (50 of 69) for placebo, and 59% (40 of 68) for lorazepam.
The most common adverse events for pregabalin and lorazepam were somnolence and dizziness, with no serious adverse events or withdrawal syndrome observed with pregabalin.

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Implication

Randomized double-blind trial demonstrates that pregabalin rapidly reduces anxiety symptoms in generalized anxiety disorder, indicating an effective alternative without typical withdrawal risks.

Cite This Study

Pande et al. (2003) studied this question.

synapsesocial.com/papers/6a11e9dc0db2e61b4b8e1c2e https://doi.org/10.1176/appi.ajp.160.3.533

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Implication

Randomized double-blind trial demonstrates that pregabalin rapidly reduces anxiety symptoms in generalized anxiety disorder, indicating an effective alternative without typical withdrawal risks.

Pregabalin in Generalized Anxiety Disorder: A Placebo-Controlled Trial

Key Points

Discussion

Implication

Cite This Study

Pregabalin in Generalized Anxiety Disorder: A Placebo-Controlled Trial

Key Points

Discussion

Implication

Cite This Study

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