Key result
In normal children, left ventricular mass indexed to body surface area was significantly higher in males compared to females (57.88 vs 50.43 g/m2, p=0.001) and correlated well with body surface area.
Why the study?
What are the normal values of left ventricular mass in healthy children, and how do they correlate with body metrics and sex?
Cross-Sectional (n=208)
No
What are the normal values of left ventricular mass in healthy children, and how do they correlate with body metrics and sex?
Absolute Event Rate: 57.88% vs 50.43%
p-value: p=0.001
This study establishes normal echocardiographic reference values for left ventricular mass in healthy Turkish children and highlights the importance of considering sex differences when evaluating for left ventricular hypertrophy.
Sex differences support sex-specific LV mass norms in children; leaves open generalizability beyond this Turkish cross-sectional cohort.
Echocardiographic measurement of left ventricular mass (LVM) is being used for the diagnosis of left ventricular hypertrophy in children with various cardiovascular diseases. The purposes of this study was to establish normal values of LVM according to weight, height and body surface area (BSA) in children and to determine the sex differences. We evaluated 208 children (143 males and 65 females), aged 1 day to 14 years who had no cardiovascular disease. The end-diastolic left ventricular internal dimension (LVIDd), end-diastolic left ventricular posterior wall thickness (LVPWd) and end-diastolic interventricular septum (IVSd) values were determined by M-mode echocardiographic examination. By using these values, left ventricular mass was calculated. The difference between LVIDd, LVPWd and LVM values of boys and girls were not statistically significant . We observed statistically significant differences between the sexes relative to IVSd and LVM/BSA values. The left ventricular mass and its components presented a good correlation with age, weight, height and BSA. The study let us know the lower and upper limits of cardiac dimensions and LVM obtained by echocardiography in normal Turkish children according to BSA. Also, as the LVM/BSA values show gender difference in children, sex should be taken in consideration while evaluating the left ventricular hypertrophy.
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Kervancıoğlu et al. (2011) conducted a cross-sectional in Healthy children (n=208). Male sex vs. Female sex was evaluated on Left ventricular mass indexed to body surface area (LVM/BSA) in g/m2 (p=0.001). In normal children, left ventricular mass indexed to body surface area was significantly higher in males compared to females (57.88 vs 50.43 g/m2, p=0.001) and correlated well with body surface area.
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