Key result
ADHD linked to higher vascular risk, up to ~42% mediated by educational attainment.
Why the study?
Does genetic liability to ADHD increase vascular risk factors?
Observational
Does genetic liability to ADHD increase vascular risk factors?
p-value: p=6.35E-14
Genetic liability to ADHD is causally associated with increased vascular risk factors, a relationship that is partially mediated by educational attainment.
May prompt vascular risk assessment in ADHD; leaves open educational mediation for prospective trials.
= 6.35E-14). Furthermore, EA was demonstrated to play a key mediating role in these causal relationships, with mediation proportions ranging from 41.67% to 11.30%. Our MR analyses supported the causal impacts of ADHD on several vascular risk factors, including BMI, WHR, WC, BF%, T2DM, early smoking initiation, cigarettes consumed per day, and CRP. Moreover, we recognized EA as a critical mediator underlying the established causal pathways. Overall, this study highlighted that individuals with ADHD were more likely to suffer from obesity, T2DM, poor lifestyle habits, and intense inflammation.
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Song et al. (2025) conducted an observational in Attention-deficit/hyperactivity disorder (ADHD) and vascular risk factors. Attention-deficit/hyperactivity disorder (exposure) was evaluated on Vascular risk factors (BMI, WHR, WC, BF%, T2DM, early smoking initiation, cigarettes consumed per day, and CRP) (p=6.35E-14). Attention-deficit/hyperactivity disorder had causal impacts on vascular risk factors including obesity and T2DM, with educational attainment mediating 11.30% to 41.67% of these relationships.
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