Key result
Self-reported baseline TIA or stroke symptoms were associated with a significantly higher risk of incident ischemic stroke compared to individuals without symptoms (HR 2.8; 95% CI 1.9-4.1).
Why the study?
Do self-reported prior positive transient ischemic attack/stroke symptoms predict future hospitalized ischemic stroke in participants with no baseline history of stroke?
Cohort (n=11,804)
Yes
Do self-reported prior positive transient ischemic attack/stroke symptoms predict future hospitalized ischemic stroke in participants with no baseline history of stroke?
Effect estimate: HR 2.8 (95% CI 1.9-4.1)
Self-reported TIA or stroke symptoms on a population questionnaire are associated with a nearly 3-fold increased risk of future hospitalized ischemic stroke in individuals without a prior stroke diagnosis.
May warrant closer monitoring in those reporting symptoms; leaves open whether symptom-based screening improves outcomes.
The association between computer diagnosis derived from a symptom questionnaire and onset of first hospitalized ischemic stroke during follow-up for up to 11 years has been assessed for 11,804 participants in the Atherosclerosis Risk in Communities Study who had no baseline history of stroke. Of these participants, 578 reported prior positive transient ischemic attack/stroke symptoms, and 265 strokes occurred during the years 1987-1998. Adjusted for age, locale, sex, and race, persons with self-reported baseline symptoms had 2.8 times the hazard rate for incident ischemic stroke of those without symptoms, with 95% confidence interval 1.9-4.1. Greater relative risk was found among younger individuals, women, African-Americans, persons not current smokers, and those with lower white blood cell count.
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Chambless et al. (2004) conducted a cohort in Ischemic stroke (n=11,804). Self-reported baseline TIA/stroke symptoms vs. No baseline symptoms was evaluated on Onset of first hospitalized ischemic stroke (HR 2.8, 95% CI 1.9-4.1). Self-reported baseline TIA or stroke symptoms were associated with a significantly higher risk of incident ischemic stroke compared to individuals without symptoms (HR 2.8; 95% CI 1.9-4.1).
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