What question did this study set out to answer?

To summarize molecular mechanisms underlying the anti-inflammatory actions of statins in atherogenesis and review evidence from clinical trials assessing cardiovascular outcomes.

April 1, 2012Current Pharmaceutical DesignOpen Access

Statins as Anti-Inflammatory Agents in Atherogenesis: Molecular Mechanisms and Lessons from the Recent Clinical Trials

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To summarize molecular mechanisms underlying the anti-inflammatory actions of statins in atherogenesis and review evidence from clinical trials assessing cardiovascular outcomes.
Synthesized molecular and physiological findings from cell cultures and animal models regarding vascular inflammation, myocardial redox status, and isoprenoid pathways.
Reviewed primary and secondary cardiovascular outcome data from major randomized clinical trials, including the JUPITER trial and studies of heart failure and chronic kidney disease.
Statins suppress vascular and myocardial inflammation, favorably regulate tissue redox states, and enhance nitric oxide bioavailability through inhibition of intracellular isoprenoid synthesis.
Clinical evidence from the JUPITER trial indicates that statin-mediated reduction of low-grade inflammation decreases coronary heart disease events in individuals without baseline disease.
Recent trials in advanced high-risk cohorts, notably patients with heart failure or chronic kidney disease, failed to demonstrate significant clinical benefits from statin therapy.

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Implication

Narrative review reveals anti-inflammatory mechanisms of statins in cardiovascular disease, indicating contrasting clinical benefits across high- and low-risk populations.

Cite This Study

Antonopoulos et al. (2012) studied this question.

synapsesocial.com/papers/6a11f05c0f45cc09baccc221 https://doi.org/10.2174/138161212799504803

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Implication

Narrative review reveals anti-inflammatory mechanisms of statins in cardiovascular disease, indicating contrasting clinical benefits across high- and low-risk populations.

Statins as Anti-Inflammatory Agents in Atherogenesis: Molecular Mechanisms and Lessons from the Recent Clinical Trials

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Discussion

Implication

Cite This Study

Statins as Anti-Inflammatory Agents in Atherogenesis: Molecular Mechanisms and Lessons from the Recent Clinical Trials

Key Points

Discussion

Implication

Cite This Study

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